Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:amphotericin_B
|
| gptkbp:activities |
gptkb:Candida_species
gptkb:Cryptococcus_neoformans inhibits DNA and RNA synthesis |
| gptkbp:appointed_by |
gptkb:amphotericin_B
oral medication |
| gptkbp:approves |
gptkb:FDA
|
| gptkbp:brand |
Ancobon
|
| gptkbp:can_be_used_with |
other antifungals
|
| gptkbp:caused_by |
hepatotoxicity
pancreatitis hypersensitivity reactions |
| gptkbp:contraindication |
pregnancy
|
| gptkbp:developed_by |
gptkb:Eli_Lilly_and_Company
|
| gptkbp:discovered_by |
1950s
|
| gptkbp:excretion |
urine
|
| https://www.w3.org/2000/01/rdf-schema#label |
flucytosine
|
| gptkbp:ingredients |
C4 H4 N2 O2
|
| gptkbp:is_available_on |
injection
capsules |
| gptkbp:is_considered |
a second-line treatment
|
| gptkbp:is_effective_against |
gptkb:Zygomycetes
gptkb:Aspergillus_species amphotericin B alone |
| gptkbp:is_enhanced_by |
gptkb:amphotericin_B
|
| gptkbp:is_monitored_by |
renal function
blood counts |
| gptkbp:is_part_of |
combination therapy
|
| gptkbp:is_used_for |
fungal infections
|
| gptkbp:is_used_in |
immunocompromised patients
HIV/ AIDS patients candidemia treatment cryptococcal meningitis treatment fungal bloodstream infections treatment fungal endocarditis treatment fungal infections in HIV patients fungal infections in cancer patients fungal infections in neutropenic patients fungal infections in patients with diabetes fungal infections in patients with heart disease fungal infections in patients with kidney disease fungal infections in patients with liver disease fungal infections in transplant patients fungal osteomyelitis treatment fungal pneumonia treatment fungal skin infections treatment fungal urinary tract infections treatment fungal infections in patients with chronic lung disease fungal infections in patients with autoimmune diseases |
| gptkbp:manager |
oral
intravenous |
| gptkbp:metabolism |
liver
|
| gptkbp:set_in |
World Health Organization's List of Essential Medicines
|
| gptkbp:side_effect |
nausea
diarrhea bone marrow suppression |
| gptkbp:suitable_for |
patients with severe renal impairment
children under 2 years patients with liver disease patients with known hypersensitivity patients with active liver disease patients with active renal disease patients with severe electrolyte imbalances |
| gptkbp:traded_on |
Ancobon
|