|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:antitoxinAvailable
|
yes
|
|
gptkbp:antitoxinType
|
horse-derived antibodies
|
|
gptkbp:biosafetyLevel
|
2
|
|
gptkbp:cause
|
diphtheria
|
|
gptkbp:decommissioned
|
formaldehyde
|
|
gptkbp:discoveredBy
|
gptkb:Emil_von_Behring
gptkb:Shibasaburo_Kitasato
|
|
gptkbp:effectOnCells
|
cell death
|
|
gptkbp:effectOnOrgans
|
nerve damage
kidney damage
heart damage
|
|
gptkbp:encodedBy
|
tox gene
|
|
gptkbp:firstDescribed
|
1888
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
diphtheria toxin
|
|
gptkbp:locatedOnChromosome
|
bacteriophage genome
|
|
gptkbp:mechanismOfAction
|
inhibits protein synthesis
ADP-ribosylates elongation factor 2
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:producedBy
|
gptkb:Corynebacterium_diphtheriae
|
|
gptkbp:recipient
|
heparin-binding EGF-like growth factor precursor
|
|
gptkbp:structure
|
A-B toxin
|
|
gptkbp:subunitAFunction
|
catalytic activity
|
|
gptkbp:subunitBFunction
|
binding to host cell receptor
|
|
gptkbp:toxicDose
|
0.1 μg/kg
|
|
gptkbp:usedFor
|
vaccine production
|
|
gptkbp:usedIn
|
diphtheria toxoid vaccine
|
|
gptkbp:bfsParent
|
gptkb:exotoxin
|
|
gptkbp:bfsLayer
|
5
|