|
gptkbp:instanceOf
|
gptkb:drug
opioid
|
|
gptkbp:ATCCode
|
gptkb:A07DA01
|
|
gptkbp:brand
|
gptkb:Lomotil
|
|
gptkbp:CASNumber
|
915-30-0
|
|
gptkbp:chemicalFormula
|
C30H32N2O2
|
|
gptkbp:combines
|
atropine
|
|
gptkbp:contraindication
|
children under 6 years
infectious diarrhea
|
|
gptkbp:controlledSubstanceSchedule
|
Schedule II (US, when alone)
Schedule V (US, when combined with atropine)
|
|
gptkbp:discoveredBy
|
gptkb:Paul_Janssen
|
|
gptkbp:discoveredIn
|
1956
|
|
gptkbp:eliminationHalfLife
|
12-14 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
diphenoxylate
|
|
gptkbp:IUPACName
|
ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
|
|
gptkbp:KEGGID
|
D07809
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
slows intestinal motility
|
|
gptkbp:MeSH_ID
|
D004180
|
|
gptkbp:metabolism
|
gptkb:difenoxin
|
|
gptkbp:molecularWeight
|
468.59 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1201202
3090
DB01081
|
|
gptkbp:riskFactor
|
anticholinergic effects (due to atropine)
respiratory depression (in overdose)
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
drowsiness
dry mouth
|
|
gptkbp:UNII
|
6D2LZ5MUDK
|
|
gptkbp:usedFor
|
treatment of diarrhea
|
|
gptkbp:bfsParent
|
gptkb:Lomotil
|
|
gptkbp:bfsLayer
|
7
|