Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gastric cancer subtype
|
| gptkbp:age |
younger patients
|
| gptkbp:associatedWith |
gptkb:signet_ring_cell_carcinoma
E-cadherin (CDH1) mutation |
| gptkbp:cause |
linitis plastica
|
| gptkbp:characteristic |
poorly cohesive cells
lacks gland formation |
| gptkbp:describedBy |
Lauren classification
|
| gptkbp:hasClinicalFeature |
early metastasis
diffuse thickening of stomach wall poorly defined tumor margins |
| gptkbp:hasGenderPrevalence |
slightly more common in females
|
| gptkbp:hasMetastasisPattern |
lymphatic spread
peritoneal dissemination |
| gptkbp:hasPrognosticMarker |
E-cadherin loss
|
| gptkbp:histology |
diffuse infiltration of stomach wall
|
| https://www.w3.org/2000/01/rdf-schema#label |
diffuse-type gastric cancer
|
| gptkbp:incidence |
less common than intestinal-type gastric cancer
|
| gptkbp:prognosis |
poor
|
| gptkbp:riskFactor |
gptkb:hereditary_diffuse_gastric_cancer_syndrome
CDH1 gene mutation family history of gastric cancer |
| gptkbp:treatment |
chemotherapy
gastrectomy targeted therapy (in some cases) |
| gptkbp:bfsParent |
gptkb:RHOA_gene
|
| gptkbp:bfsLayer |
7
|