|
gptkbp:instanceOf
|
gptkb:drug
iron chelator
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
2005
|
|
gptkbp:ATCCode
|
gptkb:V03AC03
|
|
gptkbp:brand
|
gptkb:Exjade
gptkb:Jadenu
|
|
gptkbp:CASNumber
|
201530-41-8
|
|
gptkbp:chemicalFormula
|
C21H15N3O4
|
|
gptkbp:contraindication
|
severe renal impairment
severe hepatic impairment
|
|
gptkbp:developer
|
gptkb:Novartis
|
|
gptkbp:eliminationHalfLife
|
8–16 hours
|
|
gptkbp:excretion
|
feces
|
|
gptkbp:hasSMILES
|
O=C1NC(=O)C(=C(N1)C2=CC=CC=C2)C3=CC=C(C=C3)C(=O)N
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
deferasirox
|
|
gptkbp:indication
|
gptkb:anemia
sickle cell disease
myelodysplastic syndromes
|
|
gptkbp:KEGGID
|
D03671
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds iron and facilitates its excretion
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
373.37 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
6918293
5293736
CHEMBL1200969
DB01609
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
abdominal pain
rash
increased serum creatinine
|
|
gptkbp:synonym
|
gptkb:ICL670
|
|
gptkbp:UNII
|
N9U0M0N66B
|
|
gptkbp:usedFor
|
treatment of chronic iron overload
treatment of transfusional hemosiderosis
|
|
gptkbp:bfsParent
|
gptkb:Exjade
|
|
gptkbp:bfsLayer
|
5
|