daptomycin

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:antibiotic
cyclic lipopeptide
gptkbp:approvedBy gptkb:FDA
2003
gptkbp:ATCCode J01XX09
gptkbp:brand gptkb:Cubicin
gptkbp:CASNumber 103060-53-3
gptkbp:contraindication hypersensitivity to daptomycin
gptkbp:discoveredBy gptkb:Eli_Lilly_and_Company
gptkbp:eliminationHalfLife 8 hours
gptkbp:excretion renal
gptkbp:hasMolecularFormula C72H101N17O26
https://www.w3.org/2000/01/rdf-schema#label daptomycin
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction disrupts bacterial cell membrane
gptkbp:metabolism minimal
gptkbp:molecularWeight 1620.67 g/mol
gptkbp:notEffectiveAgainst gptkb:pneumonia
Gram-negative bacteria
gptkbp:origin gptkb:Streptomyces_roseosporus
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding 92%
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect peripheral neuropathy
muscular dystrophy
elevated creatine phosphokinase
eosinophilic pneumonia
gptkbp:spectrumOfActivity Gram-positive bacteria
gptkbp:usedFor treatment of complicated skin and skin structure infections
treatment of Staphylococcus aureus bacteremia
treatment of right-sided infective endocarditis
gptkbp:bfsParent gptkb:Cubicin
gptkbp:bfsLayer 5