Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
selective estrogen receptor modulator |
| gptkbp:approvedBy |
1967
|
| gptkbp:ATCCode |
G03GB02
|
| gptkbp:brand |
Clomid
Omifin Serophene |
| gptkbp:CASNumber |
911-45-5
|
| gptkbp:chemicalFormula |
C26H28ClNO
|
| gptkbp:contraindication |
gptkb:liver_disease
gptkb:ovarian_cysts pregnancy abnormal uterine bleeding |
| gptkbp:developedBy |
gptkb:Merrell_Dow_Pharmaceuticals
|
| gptkbp:discoveredBy |
William S. Spector
|
| gptkbp:eliminationHalfLife |
5-7 days
|
| gptkbp:excretion |
urine
feces |
| gptkbp:hasEnantiomer |
enclomiphene
zuclomiphene |
| https://www.w3.org/2000/01/rdf-schema#label |
clomiphene
|
| gptkbp:IUPACName |
2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
|
| gptkbp:KEGGID |
D00297
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
blocks estrogen receptors in the hypothalamus
increases release of gonadotropins |
| gptkbp:MeSH_ID |
D002995
|
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
405.96 g/mol
|
| gptkbp:pregnancyCategory |
X
X (contraindicated) |
| gptkbp:PubChem_CID |
2800
CHEMBL1438 DB00882 |
| gptkbp:riskFactor |
multiple pregnancy
ovarian hyperstimulation syndrome |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
breast tenderness abdominal discomfort hot flashes visual disturbances ovarian enlargement |
| gptkbp:UNII |
1HRS458QUV
|
| gptkbp:usedFor |
induction of ovulation
treatment of infertility in women |
| gptkbp:usedIn |
assisted reproductive technology
|
| gptkbp:bfsParent |
gptkb:N05AG02
|
| gptkbp:bfsLayer |
7
|