|
gptkbp:instanceOf
|
gptkb:drug
gptkb:selective_estrogen_receptor_modulator
|
|
gptkbp:approvedBy
|
1967
|
|
gptkbp:ATCCode
|
G03GB02
|
|
gptkbp:brand
|
Clomid
Omifin
Serophene
|
|
gptkbp:CASNumber
|
911-45-5
|
|
gptkbp:chemicalFormula
|
C26H28ClNO
|
|
gptkbp:contraindication
|
gptkb:liver_disease
gptkb:ovarian_cysts
pregnancy
abnormal uterine bleeding
|
|
gptkbp:developedBy
|
gptkb:Merrell_Dow_Pharmaceuticals
|
|
gptkbp:discoveredBy
|
William S. Spector
|
|
gptkbp:eliminationHalfLife
|
5-7 days
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasEnantiomer
|
enclomiphene
zuclomiphene
|
|
gptkbp:IUPACName
|
2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine
|
|
gptkbp:KEGGID
|
D00297
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
blocks estrogen receptors in the hypothalamus
increases release of gonadotropins
|
|
gptkbp:MeSH_ID
|
D002995
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
405.96 g/mol
|
|
gptkbp:pregnancyCategory
|
X
X (contraindicated)
|
|
gptkbp:PubChem_CID
|
2800
CHEMBL1438
DB00882
|
|
gptkbp:riskFactor
|
multiple pregnancy
ovarian hyperstimulation syndrome
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
breast tenderness
abdominal discomfort
hot flashes
visual disturbances
ovarian enlargement
|
|
gptkbp:UNII
|
1HRS458QUV
|
|
gptkbp:usedFor
|
induction of ovulation
treatment of infertility in women
|
|
gptkbp:usedIn
|
gptkb:assisted_reproductive_technology
|
|
gptkbp:bfsParent
|
gptkb:clomifene
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
clomiphene
|