chronic spontaneous urticaria

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease gptkb:skin_disorder
gptkbp:affects	gptkb:skin subcutaneous tissue
gptkbp:alsoKnownAs	gptkb:CSU gptkb:chronic_idiopathic_urticaria
gptkbp:associatedWith	gptkb:thyroid_disease autoantibodies allergies infections
gptkbp:canBeChronic	yes
gptkbp:canBeSpontaneous	yes
gptkbp:cause	gptkb:unknown
gptkbp:causedBy	specific external triggers
gptkbp:complication	impaired quality of life
gptkbp:diagnosedBy	clinical evaluation exclusion of other causes
gptkbp:differentialDiagnosis	gptkb:contact_dermatitis gptkb:physical_urticaria urticarial vasculitis
gptkbp:duration	more than 6 weeks
gptkbp:firstLine	second-generation antihistamines
gptkbp:fourthLineTreatment	immunosuppressants
gptkbp:frequency	daily or almost daily symptoms
gptkbp:gender	more common in women
gptkbp:ICD-10_code	L50.1
gptkbp:MeSH_ID	D014581
gptkbp:onset	childhood adulthood
gptkbp:pathology	histamine release mast cell activation
gptkbp:prevalence	about 0.5-1% of the population
gptkbp:prognosis	often resolves within 2-5 years
gptkbp:riskFactor	stress autoimmune diseases
gptkbp:secondLineTreatment	increased dose antihistamines
gptkbp:symptom	gptkb:angioedema itching hives
gptkbp:thirdLineTreatment	gptkb:omalizumab
gptkbp:treatment	gptkb:omalizumab corticosteroids antihistamines leukotriene receptor antagonists
gptkbp:bfsParent	gptkb:chronic_idiopathic_urticaria gptkb:omalizumab
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	chronic spontaneous urticaria