Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
activated by calmodulin
|
| gptkbp:alsoKnownAs |
CyaA
|
| gptkbp:component |
Bordetella virulence factors
|
| gptkbp:discoveredBy |
1980s
|
| gptkbp:domain |
adenylate cyclase domain
hemolysin domain |
| gptkbp:effect |
impairs macrophage function
impairs neutrophil function |
| gptkbp:function |
inhibits host immune response
|
| gptkbp:gene |
cyaA
|
| https://www.w3.org/2000/01/rdf-schema#label |
adenylate cyclase toxin
|
| gptkbp:mechanismOfAction |
increases cAMP in host cells
|
| gptkbp:molecularWeight |
~177 kDa
|
| gptkbp:pathogenicRole |
contributes to whooping cough
|
| gptkbp:producedBy |
gptkb:Bordetella_pertussis
|
| gptkbp:recipient |
binds to CD11b/CD18 (CR3) on host cells
|
| gptkbp:secretionSystem |
Type I secretion system
|
| gptkbp:structure |
multi-domain protein
|
| gptkbp:target |
phagocytic cells
|
| gptkbp:translocationPartner |
translocates across host cell membrane
|
| gptkbp:bfsParent |
gptkb:Bordetella
|
| gptkbp:bfsLayer |
7
|