|
gptkbp:instanceOf
|
gptkb:drug
antidote
mucolytic agent
|
|
gptkbp:ATCCode
|
gptkb:R05CB01
|
|
gptkbp:brand
|
gptkb:Mucomyst
Parvolex
Acetadote
|
|
gptkbp:CASNumber
|
616-91-1
|
|
gptkbp:chemicalFormula
|
C5H9NO3S
|
|
gptkbp:contraindication
|
hypersensitivity to acetylcysteine
|
|
gptkbp:derivedFrom
|
L-cysteine
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:eliminationHalfLife
|
5.6 hours (oral)
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasSMILES
|
CC(=O)N[C@@H](CS)C(=O)O
|
|
gptkbp:hasUNII
|
WYQ7N0BPYC
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
acetylcysteine
|
|
gptkbp:IUPACName
|
(2R)-2-acetamido-3-sulfanylpropanoic acid
|
|
gptkbp:KEGGID
|
gptkb:D00221
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
breaks disulfide bonds in mucus
increases glutathione levels
|
|
gptkbp:meltingPoint
|
109-110°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
163.2 g/mol
|
|
gptkbp:pregnancyCategory
|
B (US)
B1 (Australia)
|
|
gptkbp:PubChem_CID
|
gptkb:DB06151
12035
CHEBI:28939
|
|
gptkbp:routeOfAdministration
|
oral
inhalation
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
rash
anaphylactoid reactions
|
|
gptkbp:solubility
|
soluble in water
|
|
gptkbp:synonym
|
gptkb:ACC
gptkb:N-acetylcysteine
gptkb:NAC
Acetylcysteineum
|
|
gptkbp:usedFor
|
chronic obstructive pulmonary disease
cystic fibrosis
paracetamol overdose
thick mucus clearance
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:paracetamol
|
|
gptkbp:bfsLayer
|
6
|