|
gptkbp:instanceOf
|
combination drug
|
|
gptkbp:activeIngredient
|
gptkb:codeine
acetaminophen
|
|
gptkbp:approvedBy
|
1960s
|
|
gptkbp:ATCCode
|
N02AJ06
|
|
gptkbp:brand
|
gptkb:Tylenol_#3
gptkb:Tylenol_#4
|
|
gptkbp:broadcastOn
|
gptkb:Schedule_III_(US)
gptkb:Schedule_V_(US,_lower_codeine_content)
|
|
gptkbp:contraindication
|
children under 12
severe respiratory depression
|
|
gptkbp:countryOfOperation
|
gptkb:Australia
gptkb:Canada
gptkb:United_States
|
|
gptkbp:drugInteraction
|
gptkb:beer
other CNS depressants
|
|
gptkbp:eliminationHalfLife
|
acetaminophen: 2-3 hours
codeine: 2.5-3 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:form
|
gptkb:tablet
elixir
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tylenol with codeine
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Johnson_&_Johnson
|
|
gptkbp:mechanismOfAction
|
acetaminophen is an analgesic and antipyretic
codeine is an opioid agonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notRecommendedFor
|
children after tonsillectomy or adenoidectomy
|
|
gptkbp:overdoseSymptoms
|
liver toxicity (from acetaminophen)
respiratory depression (from codeine)
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescribes
|
severe pain
moderate pain
|
|
gptkbp:prescriptionForm
|
gptkb:tablet
gptkb:water
|
|
gptkbp:riskFactor
|
addiction
respiratory depression
CYP2D6 poor metabolizers may have reduced efficacy
CYP2D6 ultra-rapid metabolizers may have increased risk of toxicity
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
constipation
drowsiness
|
|
gptkbp:usedFor
|
pain relief
cough suppression
|
|
gptkbp:bfsParent
|
gptkb:Schedule_III
|
|
gptkbp:bfsLayer
|
6
|