Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:anatomy |
expressed in neurons
|
| gptkbp:associated_with |
amino acid transport
|
| gptkbp:biochemical_pathway |
involved in metabolic pathways
|
| gptkbp:biological_importance |
critical for cellular metabolism
|
| gptkbp:cellular_function |
regulates intracellular amino acid levels
|
| gptkbp:clinical_trial |
under investigation in clinical trials
implicated in metabolic disorders important in drug interactions studied for its role in cancer therapy |
| gptkbp:clinical_use |
target for drug development
|
| gptkbp:diseases |
linked to obesity
associated with autism spectrum disorders |
| gptkbp:ecological_role |
facilitates nutrient uptake in cells
important in neurotransmitter synthesis |
| gptkbp:expression_analysis |
studied in various tissues
|
| gptkbp:function |
transporting molecules across cell membranes
|
| gptkbp:fuselage_material |
neutral amino acids
|
| gptkbp:genetic_diversity |
polymorphisms affect function
|
| gptkbp:genetic_studies |
mutations can lead to dysfunction
|
| https://www.w3.org/2000/01/rdf-schema#label |
Transporter T7
|
| gptkbp:importance |
nutrient absorption
|
| gptkbp:inhibition |
can be inhibited by certain drugs
|
| gptkbp:initiated_by |
gptkb:L-leucine
|
| gptkbp:interaction_partner |
amino acid sensors
|
| gptkbp:interacts_with |
interacts with other transport proteins
|
| gptkbp:is_expressed_in |
regulated by cellular conditions
brain and liver upregulated in certain cancers |
| gptkbp:location |
cell membrane
|
| gptkbp:pathway |
involved in amino acid metabolism
involved in various diseases |
| gptkbp:pharmacological_interest |
target for enhancing drug efficacy
|
| gptkbp:promoter |
gptkb:SLC7_A5
|
| gptkbp:regulatory_compliance |
regulated by insulin
regulated by nutrient availability |
| gptkbp:research_areas |
pharmacology
investigated for its role in therapy |
| gptkbp:research_focus |
target for enhancing drug delivery
|
| gptkbp:research_implication |
implications for nutrition and health
|
| gptkbp:role |
maintaining amino acid homeostasis
mediates cellular uptake of nutrients |
| gptkbp:species |
found in humans
|
| gptkbp:structure |
transmembrane protein
|
| gptkbp:subcellular_location |
localized in the plasma membrane
|
| gptkbp:substrate_affinity |
high affinity for branched-chain amino acids
|
| gptkbp:substrate_specificity |
specific for large neutral amino acids
|
| gptkbp:targets |
potential target for metabolic syndrome treatment
|
| gptkbp:therapeutic_application |
potential in treating metabolic disorders
|
| gptkbp:transportation |
active transport
facilitated diffusion high capacity for amino acid transport involves conformational changes |
| gptkbp:type |
solute carrier family
|
| gptkbp:weight |
approximately 50 k Da
|
| gptkbp:bfsParent |
gptkb:Transporter-43
gptkb:Transporter-44 gptkb:Transporter-57 |
| gptkbp:bfsLayer |
5
|