Time-of-Flight Mass Spectrometry

URI: https://gptkb.org/entity/Time-of-Flight_Mass_Spectrometry

GPTKB entity

Statements (53)

Predicate	Object
gptkbp:instanceOf	Mass Spectrometry Technique
gptkbp:abbreviation	gptkb:TOF-MS
gptkbp:advantage	High Speed Calibration Drift High Mass Range High Sensitivity Lower Resolution (compared to Orbitrap or FTICR) Simultaneous Detection Space Charge Effects
gptkbp:application	Forensic Science Pharmaceutical Analysis Clinical Diagnostics Environmental Analysis Biomolecule Analysis
gptkbp:component	detector Data System Ion Source Vacuum System Flight Tube
gptkbp:detects	Time Measurement
https://www.w3.org/2000/01/rdf-schema#label	Time-of-Flight Mass Spectrometry
gptkbp:introducedIn	1946
gptkbp:inventedBy	gptkb:William_E._Stephens
gptkbp:ionizationMethod	gptkb:FAB gptkb:ESI gptkb:MALDI
gptkbp:massAnalyzerType	gptkb:Time-of-Flight
gptkbp:output	Mass Spectrum
gptkbp:principle	Ions are separated by mass-to-charge ratio based on time of flight
gptkbp:range	Up to several hundred thousand Da
gptkbp:relatedTo	gptkb:Physics gptkb:Orbitrap_Mass_Spectrometry gptkb:Quadrupole_Mass_Spectrometry gptkb:Analytical_Chemistry gptkb:Electrospray_Ionization gptkb:Matrix-Assisted_Laser_Desorption/Ionization Biochemistry
gptkbp:requires	gptkb:Pulsed_Ion_Source High Vacuum
gptkbp:resolution	Typically 10,000–60,000 FWHM
gptkbp:sensorType	gptkb:Electron_Multiplier gptkb:Microchannel_Plate gptkb:Time-to-Digital_Converter
gptkbp:usedFor	gptkb:Metabolomics Proteomics Chemical Analysis Mass Analysis
gptkbp:variant	gptkb:Linear_TOF gptkb:Orthogonal_Acceleration_TOF gptkb:Reflectron_TOF gptkb:Tandem_TOF_(TOF/TOF)
gptkbp:bfsParent	gptkb:Time-Of-Flight_Detector
gptkbp:bfsLayer	6