Thalidomide

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkb:drug
gptkbp:ATCCode L04AX02
gptkbp:brand gptkb:Contergan
Thalomid
gptkbp:CASNumber 50-35-1
gptkbp:category gptkb:World_Health_Organization_essential_medicines
orphan drugs
immunosuppressants
glutarimides
phthalimides
teratogens
gptkbp:chemicalFormula C13H10N2O4
gptkbp:discoveredBy gptkb:Chemie_Grünenthal
gptkbp:discoveredIn gptkb:Germany
gptkbp:eliminationHalfLife 5–7 hours
gptkbp:firstMarketedIn gptkb:Germany
gptkbp:hasEnantiomer (R)-Thalidomide
(S)-Thalidomide
gptkbp:hasInChIKey UEJJHQNACJXSKW-UHFFFAOYSA-N
gptkbp:hasSMILES O=C1NC(=O)C2=CC=CC=C2C1=O.C1CCC(=O)NC1=O
https://www.w3.org/2000/01/rdf-schema#label Thalidomide
gptkbp:introducedIn 1957
gptkbp:IUPACName 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction anti-angiogenic
immunomodulatory
gptkbp:metabolism liver
gptkbp:molecularWeight 258.23 g/mol
gptkbp:notableEvent Thalidomide tragedy
gptkbp:notableFor causing birth defects in 1950s-1960s
gptkbp:pregnancyCategory X (contraindicated)
gptkbp:prescribes gptkb:cancer
HIV-related conditions
leprosy complications
gptkbp:prohibits pregnancy
gptkbp:regulates REMS program (US)
gptkbp:regulatoryWarning black box warning (US)
gptkbp:relatedTo gptkb:lenalidomide
gptkb:pomalidomide
gptkbp:routeOfAdministration oral
gptkbp:sideEffect birth defects
peripheral neuropathy
gptkbp:teratogenic true
gptkbp:UNII 4Z8R6ORS6L
gptkbp:usedFor gptkb:erythema_nodosum_leprosum
multiple myeloma
gptkbp:withdrawn 1961
gptkbp:bfsParent gptkb:Winter_Trees
gptkbp:bfsLayer 7