|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:antibiotic
|
|
gptkbp:affiliatedWith
|
tetracyclines
|
|
gptkbp:ATCCode
|
J01AA07
|
|
gptkbp:CASNumber
|
60-54-8
|
|
gptkbp:chemicalFormula
|
C22H24N2O8
|
|
gptkbp:contraindication
|
pregnancy
children under 8 years
|
|
gptkbp:discoveredBy
|
gptkb:Benjamin_Minge_Duggar
|
|
gptkbp:discoveredIn
|
1945
|
|
gptkbp:drugBank_ID
|
DB00759
|
|
gptkbp:eliminationHalfLife
|
6-11 hours
|
|
gptkbp:excretion
|
renal
biliary
|
|
gptkbp:genericName
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tetracycline
|
|
gptkbp:KEGGID
|
D00008
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
1953
|
|
gptkbp:mechanismOfAction
|
inhibits protein synthesis
|
|
gptkbp:meltingPoint
|
213–215 °C
|
|
gptkbp:MeSH_ID
|
D013789
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
444.435 g/mol
|
|
gptkbp:origin
|
gptkb:Streptomyces_aureofaciens
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
54675776
CHEBI:27902
CHEMBL24
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
hepatotoxicity
photosensitivity
gastrointestinal upset
tooth discoloration
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:synonym
|
gptkb:Achromycin
gptkb:Sumycin
Tetracyn
|
|
gptkbp:target
|
gptkb:bacterial_30S_ribosomal_subunit
|
|
gptkbp:UNII
|
8YQ7U8TD3F
|
|
gptkbp:usedFor
|
gptkb:plague
cholera
malaria
brucellosis
acne
bacterial infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Antibiotics
|
|
gptkbp:bfsLayer
|
4
|