Tenofovir Disoproxil Fumarate

URI: https://gptkb.org/entity/Tenofovir_Disoproxil_Fumarate
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf antiviral drug
prodrug
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2001
gptkbp:ATCCode J05AF07
gptkbp:brand gptkb:Viread
gptkbp:CASNumber 202138-50-9
gptkbp:category antiretroviral therapy
nucleotide analogue
HIV medication
hepatitis B medication
gptkbp:chemicalFormula C19H30N5O10P·C4H4O4
gptkbp:combinationTherapy gptkb:Stribild
gptkb:Truvada
gptkb:Atripla
gptkb:Complera
gptkbp:contraindication severe renal impairment
gptkbp:developedBy gptkb:Gilead_Sciences
gptkbp:drugBank_ID DB00300
gptkbp:drugInteraction gptkb:didanosine
gptkb:adefovir
gptkb:atazanavir
gptkbp:eliminationHalfLife 17 hours
gptkbp:excretion renal
gptkbp:genericAvailable yes
https://www.w3.org/2000/01/rdf-schema#label Tenofovir Disoproxil Fumarate
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction nucleotide reverse transcriptase inhibitor
gptkbp:metabolism liver
gptkbp:molecularWeight 635.5 g/mol
gptkbp:patentExpired yes
gptkbp:pregnancyCategory B (US)
B3 (Australia)
gptkbp:prodrugOf tenofovir
gptkbp:PubChem_CID 6398764
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:bone
nausea
diarrhea
renal impairment
gptkbp:UNII JX5OHT5B5K
gptkbp:usedFor HIV infection
chronic hepatitis B
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:TDF
gptkbp:bfsLayer 6