Tenofovir Disoproxil Fumarate

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:antiviral_drug gptkb:prodrug
gptkbp:approvedBy	gptkb:FDA gptkb:EMA 2001
gptkbp:ATCCode	J05AF07
gptkbp:brand	gptkb:Viread
gptkbp:CASNumber	202138-50-9
gptkbp:category	gptkb:antiretroviral_therapy gptkb:nucleotide_analogue HIV medication hepatitis B medication
gptkbp:chemicalFormula	C19H30N5O10P·C4H4O4
gptkbp:combinationTherapy	gptkb:Stribild gptkb:Truvada gptkb:Atripla gptkb:Complera
gptkbp:contraindication	severe renal impairment
gptkbp:developedBy	gptkb:Gilead_Sciences
gptkbp:drugBank_ID	DB00300
gptkbp:drugInteraction	gptkb:didanosine gptkb:adefovir gptkb:atazanavir
gptkbp:eliminationHalfLife	17 hours
gptkbp:excretion	renal
gptkbp:genericAvailable	yes
http://www.w3.org/2000/01/rdf-schema#label	Tenofovir Disoproxil Fumarate
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	gptkb:nucleotide_reverse_transcriptase_inhibitor
gptkbp:metabolism	liver
gptkbp:molecularWeight	635.5 g/mol
gptkbp:patentExpired	yes
gptkbp:pregnancyCategory	B (US) B3 (Australia)
gptkbp:prodrugOf	tenofovir
gptkbp:PubChem_CID	6398764
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	gptkb:bone nausea diarrhea renal impairment
gptkbp:UNII	JX5OHT5B5K
gptkbp:usedFor	HIV infection chronic hepatitis B
gptkbp:WHOModelListOfEssentialMedicines	yes
gptkbp:bfsParent	gptkb:TDF
gptkbp:bfsLayer	7