Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genome editing technology
|
| gptkbp:advantage |
high specificity
customizable DNA recognition |
| gptkbp:alternativeTo |
gptkb:CRISPR-Cas9
Zinc Finger Nucleases |
| gptkbp:appliesTo |
animal genome editing
plant genome editing human cell genome editing |
| gptkbp:component |
FokI nuclease domain
DNA-binding domain |
| gptkbp:developedBy |
gptkb:Joung_Lab
gptkb:Voytas_Lab |
| gptkbp:firstDescribed |
2010
|
| gptkbp:fullName |
Transcription Activator-Like Effector Nuclease technology
|
| https://www.w3.org/2000/01/rdf-schema#label |
TALEN technology
|
| gptkbp:limitation |
labor-intensive assembly
off-target effects possible |
| gptkbp:mechanismOfAction |
induces double-strand breaks in DNA
|
| gptkbp:origin |
Transcription Activator-Like Effectors from Xanthomonas bacteria
|
| gptkbp:patent |
gptkb:Sangamo_BioSciences
|
| gptkbp:recognizedBy |
specific DNA sequences
|
| gptkbp:relatedTo |
synthetic biology
genome engineering |
| gptkbp:usedFor |
genome editing
gene knockout gene insertion targeted mutagenesis |
| gptkbp:bfsParent |
gptkb:André_Choulika
|
| gptkbp:bfsLayer |
8
|