|
gptkbp:instanceOf
|
gptkb:chemical_compound
antiviral drug
sulfonamide antibiotic
|
|
gptkbp:ATCCode
|
P01BD06
|
|
gptkbp:CASNumber
|
2447-57-6
|
|
gptkbp:combinationTherapy
|
sulfadoxine/pyrimethamine
|
|
gptkbp:contraindication
|
sulfonamide allergy
|
|
gptkbp:discoveredBy
|
gptkb:Imperial_Chemical_Industries
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:eliminationHalfLife
|
7 to 9 days
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:hasMolecularFormula
|
C12H14N4O4S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sulfadoxine
|
|
gptkbp:IUPACName
|
4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits dihydropteroate synthase
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
>90%
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:Stevens-Johnson_syndrome
rash
allergic reactions
|
|
gptkbp:usedFor
|
pyrimethamine
treatment of malaria
intermittent preventive treatment in pregnancy (IPTp)
intermittent preventive treatment in infants (IPTi)
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:S/120
|
|
gptkbp:bfsLayer
|
7
|