Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Complex_2
|
| gptkbp:code |
SDHA, SDHB, SDHC, and SDHD genes
|
| gptkbp:established |
succinate
malonate |
| gptkbp:field |
nan
|
| gptkbp:game_components |
complex II of the electron transport chain
the mitochondrial respiratory chain |
| gptkbp:has |
four subunits
|
| gptkbp:has_role |
aerobic respiration
the conversion of energy in cells |
| https://www.w3.org/2000/01/rdf-schema#label |
Succinate dehydrogenase
|
| gptkbp:is_a_source_of |
fumarate in the body
|
| gptkbp:is_affected_by |
reactive oxygen species
|
| gptkbp:is_associated_with |
energy homeostasis
energy metabolism mitochondrial function cellular differentiation certain types of cancer hypoxia-induced responses |
| gptkbp:is_essential_for |
cellular respiration
energy production |
| gptkbp:is_found_in |
gptkb:physicist
gptkb:mythological_figure mitochondria plants |
| gptkbp:is_involved_in |
oxidative phosphorylation
the citric acid cycle the regulation of gene expression the detoxification of reactive metabolites the metabolism of amino acids the metabolism of carbohydrates the metabolism of fumarate the metabolism of lipids the metabolism of succinate the production of ATP the production of reactive oxygen species the regulation of cellular respiration the regulation of metabolic pathways the regulation of oxidative stress the regulation of the Krebs cycle |
| gptkbp:is_linked_to |
gptkb:psychologist
metabolic disorders cellular proliferation cellular aging cellular signaling pathways succinate accumulation |
| gptkbp:is_studied_in |
biochemistry
mitochondrial diseases |
| gptkbp:key |
aerobic glycolysis
the electron transport chain the tricarboxylic acid cycle |
| gptkbp:key_people |
aerobic metabolism
|
| gptkbp:requires |
FAD as a cofactor
|
| gptkbp:research |
bioenergetics
cancer metabolism metabolic regulation metabolic flexibility |
| gptkbp:targets |
cancer therapy
drug development therapeutic interventions metabolic engineering |
| gptkbp:was_a_catalyst_for |
the conversion of succinate to fumarate
|