Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:approves |
gptkb:2009
gptkb:FDA |
| gptkbp:availability |
prescription only
|
| gptkbp:brand |
gptkb:Sabril
|
| gptkbp:category |
gptkb:C
|
| gptkbp:class |
gptkb:Antihero
|
| gptkbp:clinical_trial |
epilepsy treatment study
|
| gptkbp:clinical_use |
long-term management of epilepsy
short-term treatment of infantile spasms |
| gptkbp:contraindication |
severe renal impairment
concurrent use of certain medications hypersensitivity to vigabatrin |
| gptkbp:counseling_services |
importance of adherence to therapy
reporting any mood changes risk of vision loss |
| gptkbp:dosage_form |
oral
|
| gptkbp:formulation |
gptkb:tablet
powder for oral solution |
| https://www.w3.org/2000/01/rdf-schema#label |
Sabril
|
| gptkbp:indication |
infantile spasms
|
| gptkbp:ingredients |
vigabatrin
|
| gptkbp:interacts_with |
gptkb:beer
other CNS depressants other antiepileptic drugs |
| gptkbp:is_monitored_by |
gptkb:weight
kidney function vision tests |
| gptkbp:manufacturer |
gptkb:Lundbeck
|
| gptkbp:marketed_as |
gptkb:Sabril
|
| gptkbp:mechanism_of_action |
inhibits GABA transaminase
|
| gptkbp:packaging |
gptkb:bottle
blister pack |
| gptkbp:patient_population |
gptkb:children
adults infants |
| gptkbp:pharmacokinetics |
excreted in urine
not extensively metabolized half-life of 5 to 9 hours |
| gptkbp:research |
investigations into long-term effects
ongoing studies on efficacy in different populations studies on combination therapy with other anticonvulsants |
| gptkbp:route_of_administration |
oral
|
| gptkbp:safety |
not recommended for use in pregnancy unless necessary
monitoring required during treatment risk of permanent vision loss not recommended for use in breastfeeding without consulting a doctor |
| gptkbp:side_effect |
gptkb:depression
fatigue irritability drowsiness weight gain peripheral neuropathy vision loss somnolence |
| gptkbp:storage |
room temperature
|
| gptkbp:used_for |
treating epilepsy
|
| gptkbp:bfsParent |
gptkb:Lundbeck
|
| gptkbp:bfsLayer |
6
|