Statements (42)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:clinical_trial
|
| gptkbp:controversy |
data analysis and reporting methods debated
|
| gptkbp:criteria |
gptkb:psychotic_depression
bipolar disorder schizophrenia |
| gptkbp:dataSharing |
publicly available dataset
|
| gptkbp:endDate |
2006
|
| gptkbp:focus |
gptkb:major_depressive_disorder
|
| gptkbp:fullName |
Sequenced Treatment Alternatives to Relieve Depression
|
| gptkbp:fundedBy |
gptkb:National_Institutes_of_Health
|
| gptkbp:goal |
to determine effectiveness of different treatment strategies for depression
|
| https://www.w3.org/2000/01/rdf-schema#label |
STAR*D study
|
| gptkbp:impact |
influenced clinical guidelines for depression treatment
|
| gptkbp:includes |
outpatients with nonpsychotic major depressive disorder
|
| gptkbp:location |
gptkb:United_States
|
| gptkbp:notableFinds |
remission rates increased with each treatment step but declined in probability
about one-third of patients achieved remission after first treatment |
| gptkbp:phase1Treatment |
gptkb:citalopram
|
| gptkbp:phase2Treatment |
switch or augment strategies
|
| gptkbp:phase3Treatment |
switch or augment strategies
|
| gptkbp:phase4Treatment |
switch or augment strategies
|
| gptkbp:principalInvestigator |
gptkb:A._John_Rush
Madhukar Trivedi |
| gptkbp:publicationYear |
2006
|
| gptkbp:publishedIn |
gptkb:American_Journal_of_Psychiatry
gptkb:New_England_Journal_of_Medicine |
| gptkbp:recognizedBy |
NCT00021528
|
| gptkbp:relatedTo |
treatment-resistant depression
antidepressant medications sequential treatment strategies |
| gptkbp:result |
remission of depression
response to antidepressant treatment |
| gptkbp:size |
4041
|
| gptkbp:sponsor |
gptkb:National_Institute_of_Mental_Health
|
| gptkbp:startYear |
2001
|
| gptkbp:studyType |
multicenter
open-label pragmatic trial |
| gptkbp:treatmentPhases |
4
|
| gptkbp:website |
https://www.nimh.nih.gov/research/research-conducted-at-nimh/research-areas/clinics-and-labs/etb/stard/index.shtml
|
| gptkbp:bfsParent |
gptkb:A._John_Rush
|
| gptkbp:bfsLayer |
8
|