|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
DCT1
DMT1
NRAMP2
|
|
gptkbp:associatedWith
|
gptkb:microcytic_anemia
iron-deficiency anemia
|
|
gptkbp:discoveredBy
|
Fleming et al.
|
|
gptkbp:encodes
|
divalent metal transporter 1
|
|
gptkbp:Entrez_Gene_ID
|
6556
ENSG00000115594
|
|
gptkbp:expressedIn
|
gptkb:duodenum
gptkb:kidney
gptkb:placenta
liver
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:function
|
involved in iron absorption
transports divalent metal ions
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11016
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC11A2
|
|
gptkbp:length
|
561 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.12
|
|
gptkbp:mRNAAlternativeSplicing
|
yes
|
|
gptkbp:mutationAssociatedWith
|
congenital hypochromic microcytic anemia
|
|
gptkbp:OMIM
|
600523
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:pathway
|
iron uptake
metal ion transport
|
|
gptkbp:product
|
DMT1 protein
|
|
gptkbp:proteinFamily
|
SLC11
|
|
gptkbp:publicTransit
|
gptkb:solute_carrier_family
|
|
gptkbp:RefSeq
|
NM_000617
|
|
gptkbp:regulates
|
regulated by hypoxia
regulated by iron levels
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
endosomal membrane
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:transportation
|
Mn2+
Zn2+
Fe2+
Cd2+
Co2+
Cu2+
Ni2+
|
|
gptkbp:UniProtID
|
Q9UHW9
|
|
gptkbp:bfsParent
|
gptkb:solute_carrier_family
|
|
gptkbp:bfsLayer
|
6
|