|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:antidote
|
gptkb:heparin
|
|
gptkbp:approvedBy
|
1930s
|
|
gptkbp:ATCCode
|
gptkb:B01AB07
|
|
gptkbp:CASNumber
|
gptkb:9009-65-8
|
|
gptkbp:chemicalFormula
|
C41H68N18O14S2
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
fish allergy
previous protamine reaction
|
|
gptkbp:discoveredBy
|
gptkb:Albrecht_Kossel
|
|
gptkbp:drugBank_ID
|
gptkb:DB09314
|
|
gptkbp:eliminationHalfLife
|
7 minutes
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:form
|
gptkb:government_agency
powder
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protamine sulfate
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds to heparin
neutralizes anticoagulant effect of heparin
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
~5,000 Da
|
|
gptkbp:origin
|
fish sperm
recombinant technology
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:pregnancyRisk
|
may cause fetal harm
|
|
gptkbp:product
|
basic protein
|
|
gptkbp:PubChem_CID
|
16129719
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
allergic reaction
hypotension
bradycardia
pulmonary edema
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:UNII
|
9H4PO4V6ZL
|
|
gptkbp:usedFor
|
heparin overdose
|
|
gptkbp:usedIn
|
vascular surgery
cardiac surgery
dialysis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Antidote
|
|
gptkbp:bfsLayer
|
5
|