Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
7
|
| gptkbp:bfsParent |
gptkb:piperaquine
|
| gptkbp:activities |
inhibits heme polymerization
|
| gptkbp:appointed_by |
oral tablet
|
| gptkbp:approves |
gptkb:2000
gptkb:China |
| gptkbp:availability |
prescription only
|
| gptkbp:brand |
gptkb:Piperaquine_phosphate
|
| gptkbp:can_be_used_with |
gptkb:artesunate
|
| gptkbp:clinical_trial |
Phase III
studied for safety in children studied for efficacy in adults studied for use in pregnancy studied in combination with other antimalarials used in endemic regions used in non-endemic regions |
| gptkbp:composed_of |
requires multiple synthetic steps
synthesized from 4-aminoquinoline derivatives |
| gptkbp:contraindication |
severe renal impairment
severe liver impairment hypersensitivity to piperaquine |
| gptkbp:developed_by |
Chinese researchers
|
| gptkbp:distribution |
widely used in Southeast Asia
|
| gptkbp:excretion |
urine
|
| gptkbp:formulation |
tablet form
suspension form |
| https://www.w3.org/2000/01/rdf-schema#label |
Piperaquine
|
| gptkbp:ingredients |
C24 H30 Cl2 N4 O2
|
| gptkbp:interacts_with |
anticoagulants
antiretrovirals anticonvulsants |
| gptkbp:invention |
patented
generic versions available |
| gptkbp:is_used_for |
treatment of malaria
|
| gptkbp:lifespan |
approximately 10 days
|
| gptkbp:marketed_as |
various brand names
|
| gptkbp:metabolism |
primarily hepatic
|
| gptkbp:provides_information_on |
used in combination therapy
CDC recommendations for malaria treatment WHO guidelines for malaria treatment |
| gptkbp:research |
ongoing studies on efficacy
studies on pediatric use studies on pharmacokinetics studies on drug interactions studies on safety in pregnancy |
| gptkbp:research_focus |
combination therapies
malaria resistance |
| gptkbp:safety_features |
generally well tolerated
|
| gptkbp:side_effect |
dizziness
headache nausea abdominal pain vomiting |
| gptkbp:storage |
store in a cool, dry place
|
| gptkbp:targets |
gptkb:Plasmodium_falciparum
gptkb:Plasmodium_vivax |
| gptkbp:type_of |
100982-00-3
|