|
gptkbp:instanceOf
|
gptkb:drug
alpha-1 adrenergic receptor agonist
|
|
gptkbp:approvedBy
|
1950s
|
|
gptkbp:ATCCode
|
C01CA06
|
|
gptkbp:bioavailability
|
38%
|
|
gptkbp:brand
|
gptkb:Sudafed_PE
gptkb:Neo-Synephrine
|
|
gptkbp:CASNumber
|
61-76-7
|
|
gptkbp:contraindication
|
gptkb:ventricular_tachycardia
narrow-angle glaucoma
severe hypertension
|
|
gptkbp:discoveredBy
|
gptkb:Eli_Lilly_and_Company
|
|
gptkbp:drugClass
|
decongestant
sympathomimetic
vasopressor
|
|
gptkbp:effect
|
pupil dilation
vasoconstriction
increased blood pressure
|
|
gptkbp:eliminationHalfLife
|
2.5 to 3 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:FDAApproved
|
yes
|
|
gptkbp:hasMolecularFormula
|
C9H13NO2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Phenylephrine
|
|
gptkbp:KEGGID
|
D08365
|
|
gptkbp:legalStatus
|
prescription only (in some countries)
over-the-counter (in some countries)
|
|
gptkbp:mechanismOfAction
|
alpha-1 adrenergic receptor agonist
|
|
gptkbp:MedlinePlusID
|
a682607
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
167.21 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
6041
CHEMBL716
DB00388
|
|
gptkbp:relatedTo
|
gptkb:pseudoephedrine
norepinephrine
epinephrine
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
anxiety
headache
hypertension
insomnia
reflex bradycardia
|
|
gptkbp:UNII
|
1WS297W6MV
|
|
gptkbp:usedFor
|
nasal congestion
hypotension
mydriasis induction
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
no
|
|
gptkbp:bfsParent
|
gptkb:Guaifenesin
|
|
gptkbp:bfsLayer
|
7
|