|
gptkbp:instanceOf
|
gptkb:drug
analgesic
antipyretic
|
|
gptkbp:alsoKnownAs
|
acetaminophen
|
|
gptkbp:antidote
|
gptkb:acetylcysteine
|
|
gptkbp:ATCCode
|
N02BE01
|
|
gptkbp:availableOn
|
gptkb:sugar
gptkb:tablet
capsule
intravenous solution
suppository
|
|
gptkbp:brand
|
gptkb:Calpol
gptkb:Crocin
gptkb:Tylenol
gptkb:Panadol
|
|
gptkbp:CASNumber
|
103-90-2
|
|
gptkbp:category
|
non-opioid analgesic
non-steroidal antipyretic
|
|
gptkbp:chemicalFormula
|
C8H9NO2
|
|
gptkbp:commonDosage
|
500 mg to 1000 mg per dose
|
|
gptkbp:contraindication
|
severe liver disease
|
|
gptkbp:discoveredBy
|
gptkb:Harmon_Northrop_Morse
|
|
gptkbp:discoveredIn
|
1877
|
|
gptkbp:eliminationHalfLife
|
1–4 hours
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Paracetamol
|
|
gptkbp:includedIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:interactionWithAlcohol
|
increases risk of liver damage
|
|
gptkbp:legalStatus
|
gptkb:OTC
|
|
gptkbp:marketedAs
|
1950s
|
|
gptkbp:maximumDailyDoseAdults
|
4 grams
|
|
gptkbp:maximumSingleDoseAdults
|
1 gram
|
|
gptkbp:mechanismOfAction
|
inhibits prostaglandin synthesis
|
|
gptkbp:meltingPoint
|
169°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
151.16 g/mol
|
|
gptkbp:origin
|
synthesized from p-aminophenol
|
|
gptkbp:overdoseSymptoms
|
acute liver failure
|
|
gptkbp:pregnancyCategory
|
AU: A
US: C (risk not ruled out)
|
|
gptkbp:prescriptionStatus
|
OTC in most countries
|
|
gptkbp:riskOfAllergy
|
rare
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
rectal
|
|
gptkbp:sideEffect
|
liver damage (in overdose)
|
|
gptkbp:soldIn
|
over 100 countries
|
|
gptkbp:solubility
|
14 mg/mL (20°C)
|
|
gptkbp:usedFor
|
pain relief
fever reduction
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Declan_McKenna
gptkb:Painkillers
gptkb:Acetaminophen
gptkb:Pyrexia
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|