|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Huntington's_disease
schizophrenia
|
|
gptkbp:biologicalProcess
|
signal transduction
3',5'-cyclic-nucleotide phosphodiesterase activity
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodes
|
phosphodiesterase 10A protein
|
|
gptkbp:Entrez_Gene_ID
|
10846
ENSG00000148842
|
|
gptkbp:expressedIn
|
gptkb:striatum
gptkb:testis
brain
|
|
gptkbp:fullName
|
phosphodiesterase 10A
|
|
gptkbp:function
|
hydrolyzes cAMP and cGMP
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:8782
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDE10A
|
|
gptkbp:inhibitedBy
|
papaverine
MP-10
TAK-063
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:mutationAssociatedWith
|
movement disorders
|
|
gptkbp:OMIM
|
604981
|
|
gptkbp:orthologInMouse
|
Pde10a
|
|
gptkbp:proteinFamily
|
phosphodiesterase family
|
|
gptkbp:regulates
|
dopaminergic signaling
glutamatergic signaling
|
|
gptkbp:UniProtID
|
Q9Y233
|
|
gptkbp:bfsParent
|
gptkb:PDE10
|
|
gptkbp:bfsLayer
|
7
|