Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
microfluidic cell culture device
|
| gptkbp:advantage |
miniaturization
customizable design enables real-time analysis mimics human physiology reduces animal use |
| gptkbp:composedOf |
biomaterials
living cells microchannels |
| gptkbp:developedBy |
gptkb:Donald_Ingber
2010s |
| gptkbp:enables |
personalized medicine
high-throughput screening reduction of animal testing |
| gptkbp:fundedBy |
gptkb:Defense_Advanced_Research_Projects_Agency
gptkb:National_Institutes_of_Health |
| gptkbp:hasApplication |
precision medicine
toxicology biomarker discovery pharmacokinetics disease modeling pharmacodynamics drug screening mechanistic studies |
| gptkbp:hasModel |
gptkb:cancer
gptkb:skin gptkb:kidney brain heart liver bone marrow tumor microenvironment gut |
| https://www.w3.org/2000/01/rdf-schema#label |
Organ-on-a-chip
|
| gptkbp:limitation |
standardization
cost scalability reproducibility integration of multiple organs long-term culture stability regulatory acceptance |
| gptkbp:relatedTo |
gptkb:lab-on-a-chip
microphysiological systems organotypic culture |
| gptkbp:SIM |
mechanical microenvironment
organ-level physiology tissue interfaces |
| gptkbp:usedFor |
biomedical research
drug development disease modeling toxicology testing |
| gptkbp:bfsParent |
gptkb:Lab-on-a-chip
|
| gptkbp:bfsLayer |
7
|