|
gptkbp:instanceOf
|
gptkb:drug
catechol-O-methyltransferase inhibitor
|
|
gptkbp:approvedBy
|
gptkb:European_Union
gptkb:United_States
2016
|
|
gptkbp:ATCCode
|
N04BX07
|
|
gptkbp:brand
|
Ongentys
|
|
gptkbp:CASNumber
|
923287-50-7
|
|
gptkbp:contraindication
|
gptkb:pheochromocytoma
paraganglioma
history of neuroleptic malignant syndrome
history of non-traumatic rhabdomyolysis
|
|
gptkbp:developedBy
|
gptkb:BIAL
|
|
gptkbp:eliminationHalfLife
|
0.7-3.2 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasMolecularFormula
|
C15H15N3O6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Opicapone
|
|
gptkbp:improves
|
levodopa bioavailability
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits catechol-O-methyltransferase (COMT)
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
333.3 g/mol
|
|
gptkbp:pregnancyCategory
|
Not assigned (US)
|
|
gptkbp:PubChem_CID
|
25154816
CHEMBL2103887
DB11632
|
|
gptkbp:reduces
|
OFF time in Parkinson's disease
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:orthostatic_hypotension
constipation
insomnia
dyskinesia
dry mouth
|
|
gptkbp:synonym
|
BIA 9-1067
|
|
gptkbp:UNII
|
6Z5B6HVF6O
|
|
gptkbp:usedFor
|
gptkb:Parkinson's_disease
|
|
gptkbp:bfsParent
|
gptkb:BIAL
|
|
gptkbp:bfsLayer
|
7
|