|
gptkbp:instanceOf
|
gptkb:antibiotic
nitrofuran
|
|
gptkbp:absorption
|
gastrointestinal tract
|
|
gptkbp:approvedBy
|
1953
|
|
gptkbp:ATCCode
|
J01XE01
|
|
gptkbp:bioavailability
|
90%
|
|
gptkbp:brand
|
Furadantin
Macrobid
Macrodantin
|
|
gptkbp:CASNumber
|
67-20-9
|
|
gptkbp:category
|
gptkb:drug
antibacterial
urinary antiseptic
|
|
gptkbp:chemicalClass
|
nitrofuran derivative
|
|
gptkbp:color
|
yellow
|
|
gptkbp:contraindication
|
renal impairment
infants under 1 month
pregnancy at term
|
|
gptkbp:discoveredBy
|
T. L. Jacob
|
|
gptkbp:discoveredIn
|
1953
|
|
gptkbp:eliminationHalfLife
|
0.3–1 hour
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C8H6N4O5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Nitrofurantoin
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits bacterial enzymes involved in carbohydrate metabolism
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
238.16 g/mol
|
|
gptkbp:notEffectiveAgainst
|
gptkb:prostatitis
pyelonephritis
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:prescribes
|
prophylaxis of recurrent urinary tract infections
uncomplicated cystitis
|
|
gptkbp:proteinBinding
|
60%
|
|
gptkbp:resistantTo
|
rare
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
headache
loss of appetite
pulmonary fibrosis
liver toxicity
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:usedFor
|
urinary tract infection
|
|
gptkbp:usedIn
|
human medicine
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:IARC_Group_2B
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|