Nicotinamide adenine dinucleotide
GPTKB entity
Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:coenzyme
|
| gptkbp:abbreviation |
NAD
|
| gptkbp:biosynthesized_from |
tryptophan
niacin (vitamin B3) |
| gptkbp:charge_(oxidized_form) |
+1
|
| gptkbp:chemicalFormula |
C21H27N7O14P2
|
| gptkbp:cofactor |
sirtuins
oxidoreductases dehydrogenases ADP-ribosyltransferases poly(ADP-ribose) polymerases |
| gptkbp:component |
adenine
ribose nicotinamide phosphate group |
| gptkbp:depleted_by |
DNA damage
PARP activation |
| gptkbp:discoveredBy |
gptkb:Arthur_Harden
William John Young |
| gptkbp:discoveredIn |
1906
|
| gptkbp:foundIn |
all living cells
|
| gptkbp:function |
metabolism
redox reactions electron capture |
| https://www.w3.org/2000/01/rdf-schema#label |
Nicotinamide adenine dinucleotide
|
| gptkbp:IUPACName |
1-[(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]-5-[(2R,3R,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl] dihydrogen diphosphate
|
| gptkbp:molecularWeight |
663.43 g/mol
|
| gptkbp:oxidized_form |
NAD+
|
| gptkbp:predecessor |
NADP+
|
| gptkbp:reduces |
gptkb:NADH
|
| gptkbp:relatedTo |
gptkb:NADH
NADP+ NADPH |
| gptkbp:restored |
niacin supplementation
nicotinamide mononucleotide nicotinamide riboside |
| gptkbp:role |
apoptosis
aging DNA repair immune response energy metabolism oxidative stress response cellular respiration redox homeostasis caloric restriction response sirtuin activation |
| gptkbp:used_in |
DNA repair
cell signaling oxidative phosphorylation fermentation glycolysis citric acid cycle |
| gptkbp:bfsParent |
gptkb:C00086
|
| gptkbp:bfsLayer |
7
|