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gptkbp:instanceOf
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gptkb:voltage-gated_potassium_channel
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gptkbp:alternativeName
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gptkb:SCN8A
Sodium channel protein type 8 subunit alpha
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gptkbp:associatedWith
|
epilepsy
SCN8A-related disorders
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gptkbp:discoveredBy
|
Catterall laboratory
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gptkbp:encodedBy
|
SCN8A gene
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gptkbp:expressedIn
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gptkb:spinal_cord
brain
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gptkbp:firstDescribed
|
1995
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gptkbp:foundIn
|
central nervous system
neurons
nodes of Ranvier
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gptkbp:function
|
initiates action potentials
propagates action potentials
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Nav1.6
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gptkbp:ionConducted
|
sodium
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gptkbp:locatedOnChromosome
|
chromosome 12q13
|
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gptkbp:molecularWeight
|
~260 kDa
|
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gptkbp:mutationAssociatedWith
|
neurological disorders
|
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gptkbp:regulates
|
phosphorylation
protein-protein interactions
ubiquitination
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gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
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gptkbp:structure
|
four homologous domains
six transmembrane segments per domain
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|
gptkbp:subunit
|
sodium channel complex
|
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gptkbp:targetOfDrug
|
antiepileptic drugs
|
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gptkbp:UniProtID
|
Q9UQD0
|
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gptkbp:YouTubeChannel
|
voltage-gated
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gptkbp:bfsParent
|
gptkb:SCN8A
|
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gptkbp:bfsLayer
|
7
|