Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
antiparasitic drug
macrocyclic lactone |
| gptkbp:administeredBy |
injection
oral route topical route |
| gptkbp:affiliatedWith |
milbemycin class
|
| gptkbp:approvalYear |
2018
|
| gptkbp:approvedBy |
gptkb:U.S._Food_and_Drug_Administration
|
| gptkbp:ATCCode |
P02CX08
|
| gptkbp:brand |
gptkb:Advantage_Multi
gptkb:ProHeart gptkb:Cydectin gptkb:quest gptkb:Moxidectin |
| gptkbp:CASNumber |
113507-06-5
|
| gptkbp:chemicalFormula |
C37H53NO8
|
| gptkbp:contraindication |
children under 12 years (for onchocerciasis)
pregnancy (caution advised) |
| gptkbp:developedBy |
human use
veterinary use |
| gptkbp:discoveredBy |
gptkb:American_Cyanamid
|
| gptkbp:firstApprovedForHumans |
onchocerciasis
|
| gptkbp:halfLife |
20-43 days (in humans)
|
| https://www.w3.org/2000/01/rdf-schema#label |
Moxidectin
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
binds to glutamate-gated chloride channels
causes paralysis and death of parasites |
| gptkbp:meltingPoint |
140-145°C
|
| gptkbp:molecularWeight |
639.8 g/mol
|
| gptkbp:origin |
derived from Streptomyces cyanogriseus
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL1908362
9832916 |
| gptkbp:relatedTo |
gptkb:ivermectin
milbemycin oxime |
| gptkbp:sideEffect |
fever
abdominal pain headache muscle pain itching eosinophilia |
| gptkbp:solubility |
practically insoluble in water
|
| gptkbp:spectrumOfActivity |
arthropods
nematodes |
| gptkbp:UNII |
8O2Q32L75X
|
| gptkbp:usedFor |
treatment of onchocerciasis
treatment of parasitic infections treatment of gastrointestinal nematodes treatment of heartworm in animals |
| gptkbp:WHOModelListOfEssentialMedicines |
not included
|
| gptkbp:bfsParent |
gptkb:Heartworms
|
| gptkbp:bfsLayer |
7
|