|
gptkbp:instanceOf
|
gptkb:antiparasitic_drug
gptkb:macrocyclic_lactone
|
|
gptkbp:administeredBy
|
injection
oral route
topical route
|
|
gptkbp:affiliatedWith
|
milbemycin class
|
|
gptkbp:approvalYear
|
2018
|
|
gptkbp:approvedBy
|
gptkb:U.S._Food_and_Drug_Administration
|
|
gptkbp:ATCCode
|
P02CX08
|
|
gptkbp:brand
|
gptkb:Advantage_Multi
gptkb:ProHeart
gptkb:Cydectin
gptkb:quest
gptkb:Moxidectin
|
|
gptkbp:CASNumber
|
113507-06-5
|
|
gptkbp:chemicalFormula
|
C37H53NO8
|
|
gptkbp:contraindication
|
children under 12 years (for onchocerciasis)
pregnancy (caution advised)
|
|
gptkbp:developedBy
|
human use
veterinary use
|
|
gptkbp:discoveredBy
|
gptkb:American_Cyanamid
|
|
gptkbp:firstApprovedForHumans
|
onchocerciasis
|
|
gptkbp:halfLife
|
20-43 days (in humans)
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds to glutamate-gated chloride channels
causes paralysis and death of parasites
|
|
gptkbp:meltingPoint
|
140-145°C
|
|
gptkbp:molecularWeight
|
639.8 g/mol
|
|
gptkbp:origin
|
derived from Streptomyces cyanogriseus
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1908362
9832916
|
|
gptkbp:relatedTo
|
gptkb:ivermectin
milbemycin oxime
|
|
gptkbp:sideEffect
|
fever
abdominal pain
headache
muscle pain
itching
eosinophilia
|
|
gptkbp:solubility
|
practically insoluble in water
|
|
gptkbp:spectrumOfActivity
|
arthropods
nematodes
|
|
gptkbp:UNII
|
8O2Q32L75X
|
|
gptkbp:usedFor
|
treatment of onchocerciasis
treatment of parasitic infections
treatment of gastrointestinal nematodes
treatment of heartworm in animals
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
not included
|
|
gptkbp:bfsParent
|
gptkb:Heartworms
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Moxidectin
|