ivermectin

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf antiparasitic drug
gptkbp:approvedBy 1981
gptkbp:ATCCode P02CF01
gptkbp:brand gptkb:Sklice
gptkb:Soolantra
gptkb:Stromectol
gptkbp:CASNumber 70288-86-7
gptkbp:chemicalFormula C48H74O14
gptkbp:contraindication children under 15 kg
lactation (caution)
pregnancy (caution)
gptkbp:discoveredBy gptkb:Satoshi_Ōmura
gptkb:William_C._Campbell
1975
gptkbp:drugClass anthelmintic
antiparasitic
gptkbp:eliminationHalfLife 12–36 hours
gptkbp:excretion feces
https://www.w3.org/2000/01/rdf-schema#label ivermectin
gptkbp:includedIn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:KEGGID D04538
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction binds to glutamate-gated chloride channels
causes paralysis and death of parasites
gptkbp:MeSH_ID D007089
gptkbp:metabolism liver
gptkbp:molecularWeight 875.1 g/mol
gptkbp:NobelPrizeYear gptkb:2015_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:notRecommendedFor COVID-19 treatment (no proven efficacy)
gptkbp:origin derived from avermectin
gptkbp:pregnancyCategory C (US)
gptkbp:producedBy gptkb:Streptomyces_avermitilis
gptkbp:PubChem_CID 6321424
CHEMBL1239
DB00602
gptkbp:routeOfAdministration oral
topical
gptkbp:sideEffect nausea
diarrhea
dizziness
itching
rash
swelling
gptkbp:UNII 91Y2202OUW
gptkbp:usedFor treatment of head lice
treatment of lymphatic filariasis
treatment of onchocerciasis
treatment of parasitic infections
treatment of river blindness
treatment of scabies
treatment of strongyloidiasis
gptkbp:bfsParent gptkb:Wuchereria_bancrofti
gptkb:Satoshi_Ōmura
gptkb:Onchocerciasis
gptkbp:bfsLayer 5