Statements (45)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
|
| gptkbp:causedBy |
amyloid-beta plaque accumulation
tau protein tangles |
| gptkbp:defines |
A progressive, neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral changes.
|
| gptkbp:diseaseHasMajorFeature |
behavioral changes
cognitive decline progressive memory loss |
| gptkbp:hasBroadSynonym |
gptkb:dementia
|
| gptkbp:hasDbXref |
DOID:10652
ICD10:G30 MeSH:D000544 MedDRA:10002023 OMIM:104300 Orphanet:399 SNOMEDCT:26929004 UMLS:C0002395 |
| gptkbp:hasExactSynonym |
gptkb:Alzheimer's_disease
|
| gptkbp:hasNarrowSynonym |
presenile dementia
|
| gptkbp:hasObsoleteParent |
Mondo:0004975
|
| gptkbp:hasSubgroup |
gard_rare
mondo_disease_groupings nci_thesaurus |
| https://www.w3.org/2000/01/rdf-schema#label |
Mondo:0008315
|
| gptkbp:inheritance |
multifactorial
|
| gptkbp:label |
gptkb:Alzheimer's_disease
|
| gptkbp:onset |
adult
|
| gptkbp:parent |
Mondo:0004975
|
| gptkbp:prevalence |
common
|
| gptkbp:riskFactor |
gptkb:APOE-e4_allele
age family history |
| gptkbp:symptom |
confusion
difficulty with language disorientation memory loss impaired judgment personality changes |
| gptkbp:synonym |
gptkb:AD
Alzheimer disease Alzheimer's dementia |
| gptkbp:treatment |
acetylcholinesterase inhibitors
supportive care NMDA receptor antagonists |
| gptkbp:bfsParent |
gptkb:von_Hippel-Lindau_disease
|
| gptkbp:bfsLayer |
7
|