|
gptkbp:instance_of
|
gptkb:blockade
|
|
gptkbp:approves
|
gptkb:1978
|
|
gptkbp:atccode
|
C07 AB02
|
|
gptkbp:available_on
|
generic drug
|
|
gptkbp:brand
|
gptkb:Lopressor
gptkb:Toprol-XL
|
|
gptkbp:casnumber
|
37350-58-0
|
|
gptkbp:chemical_formula
|
C15 H25 NO3
|
|
gptkbp:clinical_trial
|
Phase IV
Phase III
|
|
gptkbp:condition
|
gptkb:Cardiology
anxiety
hypertensive crisis
tachycardia
|
|
gptkbp:contraindication
|
gptkb:asthma
heart block
severe bradycardia
|
|
gptkbp:discovered_by
|
gptkb:Astra_Zeneca
|
|
gptkbp:dosage_form
|
100 mg
50 mg
200 mg
25 mg
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:formulation
|
gptkb:tablet
injection
extended-release tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Metoprolol
|
|
gptkbp:interacts_with
|
gptkb:diabetes
gptkb:digoxin
gptkb:verapamil
NSAIDs
|
|
gptkbp:lifespan
|
3 to 7 hours
|
|
gptkbp:mechanism_of_action
|
beta-1 adrenergic receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:patient_population
|
adults
elderly
patients with hypertension
patients with heart disease
|
|
gptkbp:research_areas
|
cardiology
pharmacology
clinical medicine
pharmacotherapy
|
|
gptkbp:route_of_administration
|
oral
intravenous
|
|
gptkbp:side_effect
|
gptkb:depression
dizziness
fatigue
bradycardia
|
|
gptkbp:used_for
|
hypertension
heart failure
arrhythmias
angina pectoris
|
|
gptkbp:bfsParent
|
gptkb:Betaloc
gptkb:Seloken
|
|
gptkbp:bfsLayer
|
6
|