Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:approves |
gptkb:FDA
1950s |
| gptkbp:available_on |
Generic drug
|
| gptkbp:brand |
gptkb:Tapazole
|
| gptkbp:chemical_formula |
C4 H6 N2 S
|
| gptkbp:clinical_use |
Adjunctive therapy in thyroid storm
Long-term management of Graves' disease Management of hyperthyroid patients Preoperative preparation for thyroid surgery |
| gptkbp:condition |
Graves' disease
Thyroid storm |
| gptkbp:contraindication |
Pregnancy
Lactation |
| gptkbp:dosage_form |
gptkb:tablet
10-40 mg daily |
| gptkbp:excretion |
Urine
|
| gptkbp:formulation |
gptkb:Sugar
gptkb:liquid |
| https://www.w3.org/2000/01/rdf-schema#label |
Methimazole
|
| gptkbp:interacts_with |
gptkb:Warfarin
Beta-blockers |
| gptkbp:is_monitored_by |
Complete blood count
Thyroid function tests |
| gptkbp:lifespan |
6-9 hours
|
| gptkbp:mechanism_of_action |
Inhibits thyroid hormone synthesis
|
| gptkbp:metabolism |
Liver
|
| gptkbp:patient_education |
Take with food
Avoid abrupt discontinuation Regular blood tests required Report signs of infection |
| gptkbp:pharmacokinetics |
Peak plasma concentration in 1-2 hours
Protein binding 90% Rapidly absorbed Thyroid peroxidase inhibitor |
| gptkbp:route_of_administration |
Oral
|
| gptkbp:side_effect |
gptkb:Fever
gptkb:Nausea Dizziness Headache Rash Joint pain Liver toxicity Agranulocytosis |
| gptkbp:storage |
Room temperature
|
| gptkbp:used_for |
Hyperthyroidism
|
| gptkbp:bfsParent |
gptkb:Feline_Hyperthyroidism
|
| gptkbp:bfsLayer |
5
|