Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Ciba-Geigy
|
| gptkbp:activities |
inhibits mitochondrial electron transport
|
| gptkbp:appointed_by |
oral tablet
|
| gptkbp:approves |
gptkb:2000
gptkb:FDA |
| gptkbp:availability |
widely available in pharmacies
|
| gptkbp:clinical_trial |
Phase III
malaria treatment malaria prophylaxis |
| gptkbp:contains |
atovaquone
proguanil |
| gptkbp:contraindication |
hypersensitivity to components
severe renal impairment |
| gptkbp:developed_by |
gptkb:Glaxo_Smith_Kline
|
| gptkbp:dosage_form |
gptkb:tablet
1 tablet daily for prevention 4 tablets for treatment on first day |
| gptkbp:duration |
3 days for acute malaria
daily for prevention |
| gptkbp:education |
take with food
report any severe side effects complete full course of treatment |
| gptkbp:formulation |
fixed-dose combination
|
| https://www.w3.org/2000/01/rdf-schema#label |
Malarone
|
| gptkbp:ingredients |
atovaquone
proguanil hydrochloride |
| gptkbp:interacts_with |
gptkb:warfarin
certain antiretroviral drugs |
| gptkbp:invention |
gptkb:2015
|
| gptkbp:is_available_on |
generic version
|
| gptkbp:is_effective_against |
P. malariae
P. ovale high against P. falciparum moderate against P. vivax |
| gptkbp:is_monitored_by |
renal function
liver function |
| gptkbp:is_used_for |
treatment of malaria
prevention of malaria |
| gptkbp:manager |
oral
|
| gptkbp:marketed_as |
Malarone brand name
|
| gptkbp:packaging |
blister pack
|
| gptkbp:price |
varies by region
|
| gptkbp:requires |
prescription only
|
| gptkbp:research_focus |
combination therapies
resistance patterns |
| gptkbp:shelf_life |
3 years
|
| gptkbp:side_effect |
headache
nausea abdominal pain diarrhea liver enzyme elevation skin rash |
| gptkbp:storage |
room temperature
|
| gptkbp:suitable_for |
severe liver disease
pregnant women without consultation children under 5 kg travelers to malaria-endemic areas |
| gptkbp:takes_place_in |
food to enhance absorption
|