|
gptkbp:instanceOf
|
antibiotic class
|
|
gptkbp:alternativeTo
|
penicillins (in allergy)
|
|
gptkbp:ATCCode
|
J01FA
|
|
gptkbp:binds
|
50S ribosomal subunit
|
|
gptkbp:category
|
bacteriostatic antibiotics
protein synthesis inhibitors
|
|
gptkbp:chemicalFormula
|
contains deoxy sugars
|
|
gptkbp:contraindication
|
hypersensitivity to macrolides
|
|
gptkbp:discoveredBy
|
gptkb:J._M._McGuire
|
|
gptkbp:discoveredIn
|
1952
|
|
gptkbp:drugInteraction
|
gptkb:warfarin
statins
CYP3A4 inhibitors
|
|
gptkbp:eliminatedIn
|
urine
bile
|
|
gptkbp:example
|
gptkb:azithromycin
gptkb:clarithromycin
gptkb:erythromycin
gptkb:roxithromycin
|
|
gptkbp:firstIsolatedFrom
|
gptkb:Streptomyces_erythreus
|
|
gptkbp:halfLife
|
varies by drug
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Macrolides
|
|
gptkbp:mechanismOfAction
|
inhibit bacterial protein synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notEffectiveAgainst
|
gptkb:Enterobacteriaceae
gptkb:Pseudomonas_aeruginosa
|
|
gptkbp:origin
|
natural and semi-synthetic
|
|
gptkbp:pregnancyCategory
|
B (varies by drug)
|
|
gptkbp:resistantTo
|
efflux pumps
methylation of 23S rRNA
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
QT prolongation
gastrointestinal upset
liver enzyme elevation
|
|
gptkbp:spectrumOfActivity
|
Gram-positive bacteria
some Gram-negative bacteria
|
|
gptkbp:structure
|
macrocyclic lactone ring
|
|
gptkbp:usedFor
|
skin infections
sexually transmitted infections
respiratory tract infections
|
|
gptkbp:usedIn
|
gptkb:Helicobacter_pylori_infection
gptkb:Mycobacterium_avium_complex
pertussis
community-acquired pneumonia
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
gptkb:azithromycin
gptkb:erythromycin
|
|
gptkbp:bfsParent
|
gptkb:Antibiotics
|
|
gptkbp:bfsLayer
|
4
|