MPTP

GPTKB entity

Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:Dragon
gptkb:chemical_compound
gptkbp:CASNumber 23007-85-4
gptkbp:category neurotoxins
dopaminergic neurotoxins
tetrahydropyridines
gptkbp:chemicalFormula C12H15N
gptkbp:discoveredIn 1970s
gptkbp:firstReported Barry Kidston
gptkbp:hasInChIKey RZJHPPFJUXUBQB-UHFFFAOYSA-N
gptkbp:hasSMILES CN1CCC=C(C1)C2=CC=CC=C2
https://www.w3.org/2000/01/rdf-schema#label MPTP
gptkbp:IUPACName 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
gptkbp:knownFor causing parkinsonism in humans
gptkbp:mechanismOfAction selective destruction of dopaminergic neurons
gptkbp:meltingPoint 37–39 °C
gptkbp:MeSH_ID D015242
gptkbp:metabolism MAO-B (monoamine oxidase B)
gptkbp:molecularWeight 173.25 g/mol
gptkbp:notableEvent 1982 California synthetic heroin case
gptkbp:notUsedAs therapeutic drug
gptkbp:predecessor MPP+
gptkbp:PubChem_CID gptkb:CHEMBL1231
4167
4316
gptkbp:relatedTo gptkb:Parkinson's_disease
gptkbp:riskFactor highly toxic
gptkbp:routeOfExposure oral
inhalation
intravenous
gptkbp:solubility soluble in water
gptkbp:toxicity neurotoxic
gptkbp:UNII 3OWP7A1K6S
gptkbp:usedIn animal models of Parkinson's disease
gptkbp:bfsParent gptkb:SSR-481
gptkbp:bfsLayer 6