|
gptkbp:instanceOf
|
gptkb:drug
antihistamine
|
|
gptkbp:ATCCode
|
gptkb:R06AX13
|
|
gptkbp:availableOn
|
gptkb:sugar
gptkb:tablet
disintegrating tablet
|
|
gptkbp:bioavailability
|
40%
|
|
gptkbp:brand
|
gptkb:Claritin
gptkb:Alavert
|
|
gptkbp:CASNumber
|
79794-75-5
|
|
gptkbp:chemicalClass
|
piperidine derivative
|
|
gptkbp:contraindication
|
severe liver impairment
|
|
gptkbp:discoveredBy
|
gptkb:Schering-Plough
|
|
gptkbp:eliminationHalfLife
|
8 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:firstGenerationAntihistamine
|
no
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:hasMolecularFormula
|
gptkb:C22H23ClN2O2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Loratadine
|
|
gptkbp:introducedIn
|
1988
|
|
gptkbp:IUPACName
|
ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
|
|
gptkbp:KEGGID
|
D08113
|
|
gptkbp:legalStatus
|
over-the-counter
|
|
gptkbp:mechanismOfAction
|
histamine H1 receptor antagonist
|
|
gptkbp:MedlinePlusID
|
a697038
|
|
gptkbp:meltingPoint
|
134°C
|
|
gptkbp:metabolism
|
liver
Desloratadine
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
B (US)
B1
|
|
gptkbp:prescriptionStatus
|
OTC in US
Rx in some countries
|
|
gptkbp:proteinBinding
|
97%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL953
gptkb:DB00455
3957
3819
|
|
gptkbp:riskOfDrowsiness
|
low
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:secondGenerationAntihistamine
|
yes
|
|
gptkbp:sideEffect
|
fatigue
headache
dry mouth
sleepiness
|
|
gptkbp:UNII
|
7AJO3BO7QN
|
|
gptkbp:usedFor
|
allergic rhinitis
urticaria
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Antihistamines_for_systemic_use
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|