Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
neurophysiological phenomenon
|
| gptkbp:abbreviation |
gptkb:LTP
|
| gptkbp:discoveredBy |
gptkb:Timothy_Bliss
gptkb:Terje_Lømo |
| gptkbp:discoveredIn |
1973
|
| gptkbp:duration |
hours to days
|
| gptkbp:firstObserved |
rabbit hippocampus
|
| gptkbp:hasModel |
memory formation
synaptic modification |
| https://www.w3.org/2000/01/rdf-schema#label |
Long-Term Potentiation
|
| gptkbp:inducedBy |
tetanus stimulation
theta-burst stimulation |
| gptkbp:influenced |
cognitive function
synaptic efficacy neuronal connectivity |
| gptkbp:influencedBy |
high-frequency stimulation
|
| gptkbp:involves |
gptkb:CREB
gptkb:Alzheimer's_disease epilepsy glutamate protein kinases presynaptic neuron postsynaptic density second messenger systems postsynaptic neuron dendritic spines synaptic vesicle release |
| gptkbp:measures |
field excitatory postsynaptic potential
|
| gptkbp:mechanismOfAction |
calcium influx
increase in synaptic strength AMPA receptor trafficking NMDA receptor activation |
| gptkbp:modulatedBy |
gptkb:acetylcholine
dopamine serotonin GABAergic inhibition |
| gptkbp:occurredIn |
gptkb:cerebral_cortex
hippocampus amygdala |
| gptkbp:oppositeProcess |
Long-Term Depression
|
| gptkbp:relatedTo |
gptkb:Hebbian_theory
gptkb:synaptic_plasticity memory learning spike-timing-dependent plasticity |
| gptkbp:requires |
gene expression
protein synthesis |
| gptkbp:studiedIn |
neuroscience
|
| gptkbp:bfsParent |
gptkb:LTP
|
| gptkbp:bfsLayer |
8
|