|
gptkbp:instance_of
|
gptkb:drug
|
|
gptkbp:bfsLayer
|
6
|
|
gptkbp:bfsParent
|
gptkb:Bruton_tyrosine_kinase
|
|
gptkbp:activities
|
BTK inhibitor
|
|
gptkbp:class
|
gptkb:Cloud_Computing_Service
|
|
gptkbp:clinical_trial
|
possible
ongoing
pending
overall response rate
overall survival
progression-free survival
NC T04507963
|
|
gptkbp:collaborations
|
with academic institutions
with other pharmaceutical companies
|
|
gptkbp:developed_by
|
gptkb:Loxo_Oncology
|
|
gptkbp:dissolved
|
soluble in DMSO
soluble in ethanol
slightly soluble in water
|
|
gptkbp:dosage_form
|
based on clinical trial protocol
|
|
gptkbp:first_described_by
|
gptkb:2020
|
|
gptkbp:frequency
|
daily
|
|
gptkbp:future_plans
|
long-term effects
biomarker identification
dosing optimization
exploring combination therapies
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LOXO-305
|
|
gptkbp:indication
|
B-cell malignancies
|
|
gptkbp:ingredients
|
C22 H24 Cl N3 O2 S
|
|
gptkbp:invention
|
patented
|
|
gptkbp:investment
|
high
|
|
gptkbp:is_effective_against
|
under investigation
|
|
gptkbp:is_tested_for
|
Phase 1
response to treatment
|
|
gptkbp:manager
|
oral
|
|
gptkbp:market
|
not approved
|
|
gptkbp:population
|
adults
|
|
gptkbp:products
|
IND application submitted
|
|
gptkbp:receives_funding_from
|
secured from investors
|
|
gptkbp:regulatory_compliance
|
under review by FDA
|
|
gptkbp:related_to
|
other BTK inhibitors
|
|
gptkbp:research
|
show promise
|
|
gptkbp:research_areas
|
oncology
|
|
gptkbp:research_focus
|
gptkb:healthcare_organization
|
|
gptkbp:safety_features
|
under evaluation
|
|
gptkbp:side_effect
|
fatigue
headache
nausea
diarrhea
rash
monitored during trials
|
|
gptkbp:sponsor
|
gptkb:Loxo_Oncology
|
|
gptkbp:status
|
gptkb:legal_case
|
|
gptkbp:student_enrollment
|
ongoing
|
|
gptkbp:target_audience
|
relapsed or refractory patients
|
|
gptkbp:targets
|
Bruton's tyrosine kinase (BTK)
|
|
gptkbp:treatment
|
under study
|
|
gptkbp:type_of
|
2034506-04-2
|
|
gptkbp:weight
|
405.96 g/mol
|
|
gptkbp:year_created
|
gptkb:2017
|