Statements (19)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
mutant
|
| gptkbp:aminoAcidChange |
c.34G>T
glycine to cysteine at position 12 p.Gly12Cys |
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
colorectal cancer pancreatic cancer |
| gptkbp:codons |
12
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:effect |
constitutive activation of KRAS protein
|
| gptkbp:foundIn |
gptkb:human
|
| gptkbp:frequencyInNSCLC |
~13%
|
| https://www.w3.org/2000/01/rdf-schema#label |
KRAS G12C
|
| gptkbp:mutationAssociatedWith |
gptkb:KRAS
|
| gptkbp:oncogenic |
true
|
| gptkbp:target |
gptkb:adagrasib
gptkb:sotorasib |
| gptkbp:bfsParent |
gptkb:sotorasib
|
| gptkbp:bfsLayer |
6
|