Ivermectin

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:drug
antineoplastic agent
gptkbp:approvedBy gptkb:FDA
1981
gptkbp:ATCCode P02CF01
gptkbp:awarded gptkb:Nobel_Prize_in_Physiology_or_Medicine_(2015,_for_discovery)
gptkbp:brand gptkb:Sklice
gptkb:Soolantra
gptkb:Stromectol
gptkbp:CASNumber 70288-86-7
gptkbp:chemicalFormula C48H74O14
gptkbp:contraindication children under 15 kg
pregnancy (caution)
gptkbp:developedBy gptkb:Merck_&_Co.
gptkbp:discoveredBy gptkb:Satoshi_Ōmura
gptkb:William_C._Campbell
gptkbp:eliminationHalfLife 12–36 hours
gptkbp:excretion feces
https://www.w3.org/2000/01/rdf-schema#label Ivermectin
gptkbp:includedIn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:KEGGID D04538
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction binds to glutamate-gated chloride channels
causes paralysis and death of parasites
gptkbp:MeSH_ID D015134
gptkbp:metabolism liver
gptkbp:molecularWeight 875.1 g/mol
gptkbp:notRecommendedFor gptkb:COVID-19_(insufficient_evidence)
gptkbp:origin derived from avermectin
gptkbp:pregnancyCategory C (US)
gptkbp:producedBy gptkb:Streptomyces_avermitilis
gptkbp:PubChem_CID 6321424
CHEMBL1239
DB00602
gptkbp:routeOfAdministration oral
topical
gptkbp:sideEffect nausea
diarrhea
dizziness
itching
rash
gptkbp:synonym gptkb:22,23-dihydroavermectin_B1
gptkbp:UNII 91Y2202OUW
gptkbp:usedFor treating head lice
treating lymphatic filariasis
treating onchocerciasis
treating parasitic infections
treating river blindness
treating scabies
treating strongyloidiasis
gptkbp:bfsParent gptkb:Heartworms
gptkbp:bfsLayer 7