|
gptkbp:instanceOf
|
gptkb:antifungal_medication
gptkb:triazole_antifungal
|
|
gptkbp:approvalYear
|
1992
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
J02AC02
|
|
gptkbp:bioavailability
|
55%
|
|
gptkbp:brand
|
Onmel
Sporanox
|
|
gptkbp:CASNumber
|
84625-61-6
|
|
gptkbp:category
|
gptkb:essential_medicine_(WHO)
|
|
gptkbp:chemicalFormula
|
C35H38Cl2N8O4
|
|
gptkbp:contraindication
|
gptkb:liver_disease
congestive heart failure
|
|
gptkbp:developedBy
|
gptkb:Belgium
|
|
gptkbp:discoveredBy
|
gptkb:Janssen_Pharmaceutica
|
|
gptkbp:eliminationHalfLife
|
17 to 42 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:interactsWith
|
gptkb:benzodiazepines
calcium channel blockers
statins
CYP3A4 inhibitors
antacids
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits ergosterol synthesis
inhibits fungal cytochrome P450 14α-demethylase
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
705.64 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
99.8%
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
abdominal pain
headache
liver enzyme elevation
|
|
gptkbp:usedFor
|
treatment of fungal infections
treatment of onychomycosis
treatment of aspergillosis
treatment of blastomycosis
treatment of coccidioidomycosis
treatment of histoplasmosis
treatment of sporotrichosis
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Itraconazole
|