Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
antifungal medication
triazole antifungal |
| gptkbp:approvalYear |
1992
|
| gptkbp:approvedBy |
gptkb:FDA
|
| gptkbp:ATCCode |
J02AC02
|
| gptkbp:bioavailability |
55%
|
| gptkbp:brand |
Onmel
Sporanox |
| gptkbp:CASNumber |
84625-61-6
|
| gptkbp:category |
gptkb:essential_medicine_(WHO)
|
| gptkbp:chemicalFormula |
C35H38Cl2N8O4
|
| gptkbp:contraindication |
gptkb:liver_disease
congestive heart failure |
| gptkbp:developedBy |
gptkb:Belgium
|
| gptkbp:discoveredBy |
gptkb:Janssen_Pharmaceutica
|
| gptkbp:eliminationHalfLife |
17 to 42 hours
|
| gptkbp:excretion |
urine
feces |
| https://www.w3.org/2000/01/rdf-schema#label |
Itraconazole
|
| gptkbp:interactsWith |
gptkb:benzodiazepines
calcium channel blockers statins CYP3A4 inhibitors antacids |
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
inhibits ergosterol synthesis
inhibits fungal cytochrome P450 14α-demethylase |
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
705.64 g/mol
|
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:proteinBinding |
99.8%
|
| gptkbp:routeOfAdministration |
oral
intravenous |
| gptkbp:sideEffect |
nausea
vomiting diarrhea abdominal pain headache liver enzyme elevation |
| gptkbp:usedFor |
treatment of fungal infections
treatment of onychomycosis treatment of aspergillosis treatment of blastomycosis treatment of coccidioidomycosis treatment of histoplasmosis treatment of sporotrichosis |
| gptkbp:bfsParent |
gptkb:Zentiva
|
| gptkbp:bfsLayer |
7
|