Statements (77)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:vaccine
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Il-2_Sturmovik
|
| gptkbp:associated_with |
gptkb:healthcare_organization
gptkb:psychologist gptkb:rheumatoid_arthritis autoimmune diseases sepsis psoriasis chronic obstructive pulmonary disease type 1 diabetes chronic inflammatory diseases |
| gptkbp:enhances |
regulatory T cells
|
| gptkbp:established |
T cell activation
IL-6 production NK cell activity Th1 cell differentiation neutrophil activation dendritic cell maturation macrophage activation pro-inflammatory cytokines Th17 differentiation IL-1 production IL-12 production Ig E synthesis TGF-beta production TNF-alpha production Th1 and Th2 responses inflammatory cytokine production macrophage cytokine production |
| gptkbp:function |
anti-inflammatory response
|
| https://www.w3.org/2000/01/rdf-schema#label |
Il-10
|
| gptkbp:influences |
cellular signaling pathways
T cell differentiation dendritic cell function immune cell proliferation immune cell interactions B cell differentiation cytokine networks |
| gptkbp:is_involved_in |
gptkb:asthma
gptkb:healthcare_organization wound healing neuroinflammation cancer progression viral infections chronic infections immune regulation allergic responses chronic pain. HIV infection response |
| gptkbp:is_vulnerable_to |
IL-10 receptor
|
| gptkbp:produced_by |
gptkb:T_cells
B cells adipocytes fibroblasts mast cells response to infection neutrophils epithelial cells regulatory T cells |
| gptkbp:promoter |
I L10
|
| gptkbp:promotes |
cell survival
immune tolerance tissue repair immune suppression Th2 responses B cell survival anti-tumor immunity tolerance in transplantation |
| gptkbp:regulates |
inflammatory responses
T cell responses immune homeostasis cytokine expression immune responses to pathogens |
| gptkbp:research_areas |
inflammatory diseases
|
| gptkbp:role |
tumor immunity
|
| gptkbp:security_features |
monocytes
|