Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:monoclonal_antibody
|
| gptkbp:abundanceInHumanIgG |
~60% of total IgG
|
| gptkbp:binds |
Fc gamma receptor I (CD64)
Fc gamma receptor II (CD32) Fc gamma receptor III (CD16) |
| gptkbp:foundIn |
gptkb:human
gptkb:mouse |
| gptkbp:function |
antibody-dependent cellular cytotoxicity
opsonization complement activation neutralization of pathogens |
| gptkbp:gene |
gptkb:IGHG1
|
| gptkbp:halfLifeInSerum |
~21 days
|
| gptkbp:heavyChainType |
gamma 1
|
| https://www.w3.org/2000/01/rdf-schema#label |
IgG1 antibody
|
| gptkbp:isotypeOf |
gptkb:IgG
|
| gptkbp:medicalUse |
therapeutic monoclonal antibodies
|
| gptkbp:molecularWeight |
~150 kDa
|
| gptkbp:producedBy |
plasma cells
|
| gptkbp:structure |
two heavy chains and two light chains
|
| gptkbp:subclassOf |
gptkb:immunoglobulin_G
|
| gptkbp:bfsParent |
gptkb:UniProt:P01848
gptkb:adalimumab |
| gptkbp:bfsLayer |
7
|