Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:biologicalProcess |
purine nucleotide biosynthesis
|
| gptkbp:cofactor |
NAD+
potassium ion |
| gptkbp:EC_number |
1.1.1.205
|
| gptkbp:fullName |
Inosine-5'-monophosphate dehydrogenase
|
| gptkbp:function |
catalyzes the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP)
|
| gptkbp:gene |
gptkb:IMPDH1
IMPDH2 |
| https://www.w3.org/2000/01/rdf-schema#label |
IMPDH
|
| gptkbp:inhibitedBy |
gptkb:mycophenolic_acid
ribavirin |
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:mutationAssociatedWith |
mutations in IMPDH1 cause retinitis pigmentosa
|
| gptkbp:organism |
found in eukaryotes
found in bacteria |
| gptkbp:pathway |
de novo guanine nucleotide biosynthesis
|
| gptkbp:PDB |
1B3O
1JR1 |
| gptkbp:product |
gptkb:NADH
gptkb:xanthosine_monophosphate_(XMP) |
| gptkbp:significance |
target for antiviral drugs
target for immunosuppressive drugs |
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
inosine monophosphate (IMP)
|
| gptkbp:bfsParent |
gptkb:IMPDH1_gene
|
| gptkbp:bfsLayer |
7
|