Horner–Wadsworth–Emmons reaction

GPTKB entity

Statements (24)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:alsoKnownAs gptkb:HWE_reaction
gptkbp:application organic synthesis
pharmaceutical synthesis
gptkbp:basisFor strong base (e.g., sodium hydride, potassium tert-butoxide)
gptkbp:category name reaction
carbonyl chemistry
gptkbp:criteria E-alkene (trans-alkene) preference
gptkbp:firstReported 1958
https://www.w3.org/2000/01/rdf-schema#label Horner–Wadsworth–Emmons reaction
gptkbp:mechanismOfAction phosphonate carbanion attacks carbonyl
gptkbp:namedAfter gptkb:Leopold_Horner
gptkb:William_D._Emmons
gptkb:William_S._Wadsworth
gptkbp:product alkene
gptkbp:reactant aldehyde
ketone
phosphonate-stabilized carbanion
gptkbp:relatedTo gptkb:Wittig_reaction
gptkbp:solvent polar aprotic solvent
gptkbp:type carbon–carbon bond formation
olefination
gptkbp:bfsParent gptkb:Leopold_Horner
gptkbp:bfsLayer 5